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microPIR database

Title: microPIR: An Integrated Database of MicroRNA Target Sites within Human Promoter Sequences
journal: PLoS ONE
authors: Piriyapongsa J, Bootchai C, Ngamphiw C, Tongsima S
year: 2012

Title: microPIR2: a comprehensive database for human-mouse comparative study of microRNA-promoter interactions
journal: Database
authors: Piriyapongsa J, Bootchai C, Ngamphiw C, Tongsima S
year: 2014


microPIR is our previous public database containing over 15 million predicted microRNA target sites located within human promoter sequences. These predicted targets are presented along with their related genomic and experimental data, making the microPIR database the most comprehensive repository of microRNA promoter target sites. Here we describe major updates of the microPIR database including new target site predictions in the mouse genome and revised human target predictions. The update database microPIR2 now provide approximately 80 million human and 40 million mouse predicted target sites. In addition to being a reference database,       microPIR2 is a tool for comparative analysis of target sites on the promoters of human-mouse orthologous genes. In particular, this new feature was designed to identify potential microRNA-promoter interactions conserved between species that could be stronger candidates for further experimental validation. We also incorporated additional supporting information to microPIR2 such as nuclear and cytoplasmic localization of microRNAs and miRNA-disease association. Extra search features were also implemented to enable various investigations of targets of interest.

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